Interactive Comorbidity between Opioid Drug Abuse and HIV-1 Tat : Chronic Exposure Augments Spine Loss and Sublethal Dendritic Pathology in Striatal Neurons

HIV-1 infection predisposes the central nervous system to damage by opportunistic infections and environmental insults. Such maladaptive plasticity may underlie the exaggerated comorbidity seen with HIV-1 infection and opioid abuse. Although morphine and HIV-1 Tat synergize at high concentrations to...

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Main Authors: Fitting, Sylvia, Xu, Ruqiang, Bull, Cecilia, Buch, Shreya K., El-Hage, Nazira, Nath, Avindra, Knapp, Pamela E., Hauser, Kurt F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2010
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928972/
https://ncbi.nlm.nih.gov/pubmed/20651230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090945
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