Differential involvement of p38 and JNK MAP kinases in HIV-1 Tat and gp120-induced apoptosis and neurite degeneration in striatal neurons

The role of p38 and c-jun-N-terminal kinases 1/2 (JNK), members of the mitogen-activated protein kinase (MAPK) family, in mediating the toxic effects of HIV-1 Tat and gp120 were explored in primary mouse striatal neurons in vitro. Both Tat and gp120 caused significant increases in p38 and JNK MAPK p...

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Publicado en:Neuroscience
Main Authors: Singh, Indrapal N., El-Hage, Nazira, Campbell, Megan E., Lutz, Sarah E., Knapp, Pamela E., Nath, Avindra, Hauser, Kurt F.
Formato: Artigo
Idioma:Inglês
Publicado: 2005
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4310730/
https://ncbi.nlm.nih.gov/pubmed/16111829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2005.05.028
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