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Interactive Comorbidity between Opioid Drug Abuse and HIV-1 Tat : Chronic Exposure Augments Spine Loss and Sublethal Dendritic Pathology in Striatal Neurons
HIV-1 infection predisposes the central nervous system to damage by opportunistic infections and environmental insults. Such maladaptive plasticity may underlie the exaggerated comorbidity seen with HIV-1 infection and opioid abuse. Although morphine and HIV-1 Tat synergize at high concentrations to...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Investigative Pathology
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2928972/ https://ncbi.nlm.nih.gov/pubmed/20651230 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090945 |
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