Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens

Despite abundant expression of DNA methyltransferases (Dnmt’s) in brain, the regulation and behavioral role of DNA methylation remain poorly understood. We find that Dnmt3a expression is regulated in mouse nucleus accumbens (NAc) by chronic cocaine and chronic social defeat stress. Moreover, NAc spe...

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Autori principali: LaPlant, Quincey, Vialou, Vincent, Covington, Herbert E, Dumitriu, Dani, Feng, Jian, Warren, Brandon, Maze, Ian, Dietz, David M, Watts, Emily L., Iñiguez, Sergio D, Koo, Ja Wook, Mouzon, Ezekiell, Renthal, William, Hollis, Fiona, Wang, Hui, Noonan, Michele A., Ren, Yanhua, Eisch, Amelia J., Bolaños, Carlos A., Kabbaj, Mohamed, Xiao, Guanghua, Neve, Rachael L, Hurd, Yasmin L, Oosting, Ronald S, Fan, Gouping, Morrison, John H., Nestler, Eric J
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928863/
https://ncbi.nlm.nih.gov/pubmed/20729844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2619
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