Leptin upregulates VEGF in breast cancer via canonic and non-canonical signaling pathways and NFκB/HIF-1α activation

High levels of VEGF and leptin are strongly linked to worse prognosis of breast cancer. Leptin signalling up-regulates VEGF in human and mouse mammary tumor cells (MT), but the specific molecular mechanisms are largely unknown. Pharmacologic and genetic approaches were used to dissect the mechanism...

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Autores principales: Gonzalez-Perez, Ruben R., Guo, Shanchun, Watters, Amber, Zhou, Weiqiang, Leibovich, Samuel J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928711/
https://ncbi.nlm.nih.gov/pubmed/20466060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2010.05.003
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