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Leptin upregulates VEGF in breast cancer via canonic and non-canonical signaling pathways and NFκB/HIF-1α activation
High levels of VEGF and leptin are strongly linked to worse prognosis of breast cancer. Leptin signalling up-regulates VEGF in human and mouse mammary tumor cells (MT), but the specific molecular mechanisms are largely unknown. Pharmacologic and genetic approaches were used to dissect the mechanism...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2928711/ https://ncbi.nlm.nih.gov/pubmed/20466060 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2010.05.003 |
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