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Opposing functions of two sub-domains of the SNARE-complex in neurotransmission

The SNARE-complex consisting of synaptobrevin-2/VAMP-2, SNAP-25 and syntaxin-1 is essential for evoked neurotransmission and also involved in spontaneous release. Here, we used cultured autaptic hippocampal neurons from Snap-25 null mice rescued with mutants challenging the C-terminal, N-terminal an...

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Main Authors: Weber, Jens P, Reim, Kerstin, Sørensen, Jakob B
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928689/
https://ncbi.nlm.nih.gov/pubmed/20562829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.130
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