Hedgehog controls neural stem cells through p53-independent regulation of Nanog

Hedgehog (Hh) pathway has a pivotal function in development and tumorigenesis, processes sustained by stem cells (SCs). The transcription factor Nanog controls stemness acting as a key determinant of both embryonic SC self-renewal and differentiated somatic cells reprogramming to pluripotency, in co...

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Main Authors: Po, Agnese, Ferretti, Elisabetta, Miele, Evelina, De Smaele, Enrico, Paganelli, Arianna, Canettieri, Gianluca, Coni, Sonia, Di Marcotullio, Lucia, Biffoni, Mauro, Massimi, Luca, Di Rocco, Concezio, Screpanti, Isabella, Gulino, Alberto
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928686/
https://ncbi.nlm.nih.gov/pubmed/20581804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.131
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