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The transcription inhibitor lipiarmycin blocks DNA fitting into the RNA polymerase catalytic site

Worldwide spreading of drug-resistant pathogens makes mechanistic understanding of antibiotic action an urgent task. The macrocyclic antibiotic lipiarmycin (Lpm), which is under development for clinical use, inhibits bacterial RNA polymerase (RNAP) by an unknown mechanism. Using genetic and biochemi...

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書誌詳細
主要な著者: Tupin, Audrey, Gualtieri, Maxime, Leonetti, Jean-Paul, Brodolin, Konstantin
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928680/
https://ncbi.nlm.nih.gov/pubmed/20562828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.135
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