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The transcription inhibitor lipiarmycin blocks DNA fitting into the RNA polymerase catalytic site
Worldwide spreading of drug-resistant pathogens makes mechanistic understanding of antibiotic action an urgent task. The macrocyclic antibiotic lipiarmycin (Lpm), which is under development for clinical use, inhibits bacterial RNA polymerase (RNAP) by an unknown mechanism. Using genetic and biochemi...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2928680/ https://ncbi.nlm.nih.gov/pubmed/20562828 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.135 |
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