PTP-PEST controls motility, adherens junction assembly, and Rho GTPase activity in colon cancer cells

An important step in carcinoma progression is loss of cell-cell adhesion leading to increased invasion and metastasis. We show here that the protein tyrosine phosphatase, PTP-PEST, is a critical regulator of cell-cell junction integrity and epithelial cell motility. Using colon carcinoma cells, we s...

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Detalhes bibliográficos
Main Authors: Espejo, Rosario, Rengifo-Cam, William, Schaller, Michael D., Evers, B. Mark, Sastry, Sarita K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2010
Assuntos:
Extracellular Matrix, Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928632/
https://ncbi.nlm.nih.gov/pubmed/20519451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00148.2010
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