PTP-PEST targets a novel tyrosine site in p120 catenin to control epithelial cell motility and Rho GTPase activity

Tyrosine phosphorylation is implicated in regulating the adherens junction protein, p120 catenin (p120), however, the mechanisms are not well defined. Here, we show, using substrate trapping, that p120 is a direct target of the protein tyrosine phosphatase, PTP-PEST, in epithelial cells. Stable shRN...

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Main Authors: Espejo, Rosario, Jeng, Yowjiun, Paulucci-Holthauzen, Adriana, Rengifo-Cam, William, Honkus, Krysta, Anastasiadis, Panos Z., Sastry, Sarita K.
格式: Artigo
語言:Inglês
出版: The Company of Biologists 2014
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007762/
https://ncbi.nlm.nih.gov/pubmed/24284071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.120154
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