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The effects of the small GTPase RhoA on the muscarinic contraction of airway smooth muscle result from its role in regulating actin polymerization

The small GTPase RhoA increases the Ca(2+) sensitivity of smooth muscle contraction and myosin light chain (MLC) phosphorylation by inhibiting the activity of MLC phosphatase. RhoA is also a known regulator of cytoskeletal dynamics and actin polymerization in many cell types. In airway smooth muscle...

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Autors principals: Zhang, Wenwu, Du, Liping, Gunst, Susan J.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928621/
https://ncbi.nlm.nih.gov/pubmed/20445174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00118.2010
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