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The effects of the small GTPase RhoA on the muscarinic contraction of airway smooth muscle result from its role in regulating actin polymerization
The small GTPase RhoA increases the Ca(2+) sensitivity of smooth muscle contraction and myosin light chain (MLC) phosphorylation by inhibiting the activity of MLC phosphatase. RhoA is also a known regulator of cytoskeletal dynamics and actin polymerization in many cell types. In airway smooth muscle...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Physiological Society
2010
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2928621/ https://ncbi.nlm.nih.gov/pubmed/20445174 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00118.2010 |
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