Novel plasminogen activator inhibitor-1-derived peptide protects against impairment of cerebrovasodilation after photothrombosis through inhibition of JNK MAPK

The sole FDA-approved treatment for acute stroke is recombinant tissue-type plasminogen activator (rtPA). However, rtPA aggravates the impairment of cerebrovasodilation induced by global hypoxia/ischemia; this impairment is attenuated by the preinjury treatment with the plasminogen activator inhibit...

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Main Authors: Armstead, William M., Riley, John, Kiessling, J. Willis, Cines, Douglas B., Higazi, Abd Al-Roof
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2010
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928614/
https://ncbi.nlm.nih.gov/pubmed/20538898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00256.2010
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