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Targeted Deletion of Hepatic Igf1 in TRAMP Mice Leads to Dramatic Alterations in the Circulating Insulin-Like Growth Factor Axis but Does Not Reduce Tumor Progression

The role of systemic and local insulin-like growth factor I (IGF-I) in the development of prostate cancer is still controversial. Transgenic adenocarcinoma mouse prostate (TRAMP) mice express the SV40 T-antigen under the control of the probasin promoter, and spontaneously develop prostate cancer. We...

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التفاصيل البيبلوغرافية
المؤلفون الرئيسيون:	Anzo, Makoto, Cobb, Laura J., Hwang, David L., Mehta, Hemal, Said, Jonathan W., Yakar, Shoshana, LeRoith, Derek, Cohen, Pinchas
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	2008
الموضوعات:	Article
الوصول للمادة أونلاين:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2928555/ https://ncbi.nlm.nih.gov/pubmed/18451161 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-07-3165
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Targeted Deletion of Hepatic Igf1 in TRAMP Mice Leads to Dramatic Alterations in the Circulating Insulin-Like Growth Factor Axis but Does Not Reduce Tumor Progression

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