Circulating levels of IGF-1 directly regulate bone growth and density

IGF-1 is a growth-promoting polypeptide that is essential for normal growth and development. In serum, the majority of the IGFs exist in a 150-kDa complex including the IGF molecule, IGF binding protein 3 (IGFBP-3), and the acid labile subunit (ALS). This complex prolongs the half-life of serum IGFs...

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Main Authors: Yakar, Shoshana, Rosen, Clifford J., Beamer, Wesley G., Ackert-Bicknell, Cheryl L., Wu, Yiping, Liu, Jun-Li, Ooi, Guck T., Setser, Jennifer, Frystyk, Jan, Boisclair, Yves R., LeRoith, Derek
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2002
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC151128/
https://ncbi.nlm.nih.gov/pubmed/12235108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI15463
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