Elevated Circulating IGF-I Promotes Mammary Gland Development and Proliferation

Animal studies have shown that IGF-I is essential for mammary gland development. Previous studies have suggested that local IGF-I rather than circulating IGF-I is the major mediator of mammary gland development. In the present study we used the hepatic IGF-I transgenic (HIT) and IGF-I knockout/HIT (...

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Hlavní autoři: Cannata, Dara, Lann, Danielle, Wu, Yingjie, Elis, Sebastien, Sun, Hui, Yakar, Shoshana, Lazzarino, Deborah A., Wood, Teresa L., LeRoith, Derek
Médium: Artigo
Jazyk:Inglês
Vydáno: The Endocrine Society 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2999497/
https://ncbi.nlm.nih.gov/pubmed/20926579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2010-0792
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