RasGRP1 stimulation enhances ubiquitination and endocytosis of the sodium-chloride cotransporter

The sodium-chloride cotransporter (NCC) is the principal salt-absorptive pathway in the distal convoluted tubule. Recently, we described a novel pathway of NCC regulation in which phorbol esters (PE) stimulate Ras guanyl-releasing protein 1 (RasGRP1), triggering a cascade ultimately activating ERK1/...

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Bibliografische gegevens
Hoofdauteurs: Ko, Benjamin, Kamsteeg, Erik-Jan, Cooke, Leslie L., Moddes, Lauren N., Deen, Peter M. T., Hoover, Robert S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Physiological Society 2010
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928521/
https://ncbi.nlm.nih.gov/pubmed/20392800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00441.2009
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