The Redox Enzyme p66Shc Contributes to Diabetes and Ischemia-Induced Delay in Cutaneous Wound Healing

OBJECTIVE: The redox enzyme p66Shc produces hydrogen peroxide and triggers proapoptotic signals. Genetic deletion of p66Shc prolongs life span and protects against oxidative stress. In the present study, we evaluated the role of p66Shc in an animal model of diabetic wound healing. RESEARCH DESIGN AN...

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Detalhes bibliográficos
Main Authors: Fadini, Gian Paolo, Albiero, Mattia, Menegazzo, Lisa, Boscaro, Elisa, Pagnin, Elisa, Iori, Elisabetta, Cosma, Chiara, Lapolla, Annunziata, Pengo, Vittorio, Stendardo, Massimo, Agostini, Carlo, Pelicci, Pier Giuseppe, Giorgio, Marco, Avogaro, Angelo
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2010
Assuntos:
Complications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2927954/
https://ncbi.nlm.nih.gov/pubmed/20566667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-1727
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