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K33-linked polyubiquitination of T cell receptor-ζ regulates T cell activation by modulating its endocytosis-independent phosphorylation
Tagging the cell surface receptor with ubiquitin is believed to provide a signal for the endocytic pathway. E3 ubiquitin ligases such as Cbl-b and Itch have been implicated in T cell activation and tolerance induction. However, the underlying mechanisms remain unclear. Here we describe that in mice...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2927827/ https://ncbi.nlm.nih.gov/pubmed/20637659 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2010.07.002 |
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