Preclinical correction of human Fanconi anemia complementation group A bone marrow cells using a safety-modified lentiviral vector

One of the major hurdles for the development of gene therapy for Fanconi anemia (FA) is the increased sensitivity of FA stem cells to free radical-induced DNA damage during ex vivo culture and manipulation. To minimize this damage, we have developed a brief transduction procedure for lentivirus vect...

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Detalhes bibliográficos
Main Authors: Becker, Pamela S., Taylor, Jason A., Trobridge, Grant D., Zhao, Xin, Beard, Brian C, Chien, Sylvia, Adair, Jennifer, Kohn, Donald B., Wagner, John E., Shimamura, Akiko, Kiem, Hans-Peter
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2927804/
https://ncbi.nlm.nih.gov/pubmed/20485382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2010.62
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