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A defect in cytosolic carboxypeptidase 1 (Nna1) causes autophagy in Purkinje cell degeneration mouse brain

Purkinje cell degeneration (pcd) is a mouse mutant which is characterized by post-natal degeneration of selective cell types. The pcd mutation was mapped to a gene encoding a cytosolic carboxypeptidase-like protein (CCP), named CCP1/Nna1. Many neurons in pcd mice show increased levels of autophagy,...

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Autores principales: Berezniuk, Iryna, Fricker, Lloyd D.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2927707/
https://ncbi.nlm.nih.gov/pubmed/20484972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.6.4.11813
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