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Differential effects of cisplatin and MNNG on dna mutants of Escherichia coli

DNA mismatch repair (MMR) in mammalian cells or Escherichia coli dam mutants increases the cytotoxic effects of cisplatin and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). We found that, unlike wildtype, the dnaE486 (alpha catalytic subunit of DNA polymerase III holoenzyme) mutant, and a DnaX (c...

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Bibliographic Details
Main Authors: Calmann, Melissa A., Marinus, M.G.
Format: Artigo
Language:Inglês
Published: 2005
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2927670/
https://ncbi.nlm.nih.gov/pubmed/16144703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrfmmm.2005.06.030
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