Synergistic induction of local glucocorticoid generation by inflammatory cytokines and glucocorticoids: implications for inflammation associated bone loss

OBJECTIVES: Synovial fibroblasts and osteoblasts generate active glucocorticoids by means of the 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme. This activity increases in response to proinflammatory cytokines or glucocorticoids. During inflammatory arthritis synovium and bone are exposed...

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Bibliographic Details
Main Authors: Kaur, K, Hardy, R, Ahasan, M M, Eijken, M, van Leeuwen, J P, Filer, A, Thomas, A M, Raza, K, Buckley, C D, Stewart, P M, Rabbitt, E H, Hewison, M, Cooper, M S
Format: Artigo
Language:Inglês
Published: BMJ Group 2009
Subjects:
Basic and Translational Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2927616/
https://ncbi.nlm.nih.gov/pubmed/19549618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/ard.2009.107466
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