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Multiple roles for the first transmembrane domain of GABA(A) receptor subunits in neurosteroid modulation and spontaneous channel activity
Neurosteroids exert potent physiological effects by allosterically modulating synaptic and extrasynaptic GABA(A) receptors. Some endogenous neurosteroids, such as 3α, 21-dihydroxy-5β-pregnan-20-one (5α, 3α-THDOC), potentiate GABA(A) receptor function by interacting with a binding pocket defined by c...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2927215/ https://ncbi.nlm.nih.gov/pubmed/20193738 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2010.02.058 |
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