Residues in the first transmembrane domain of the Caenorhabditis elegans GABA(A) receptor confer sensitivity to the neurosteroid pregnenolone sulfate

1. The GABA(A) receptor is a target of endogenous and synthetic neurosteroids. Little is known about the residues required for neurosteroid action on GABA(A) receptors. We have investigated pregnenolone sulfate (PS) inhibition of the Caenorhabditis elegans UNC-49 GABA receptor, a close homolog of th...

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Autores principales: Wardell, Bryan, Marik, Purba S, Piper, David, Rutar, Tina, Jorgensen, Erik M, Bamber, Bruce A
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2006
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Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1617053/
https://ncbi.nlm.nih.gov/pubmed/16547524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706719
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