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Down-regulation of tumor suppressor gene FEZ1/LZTS1 in breast carcinoma involves promoter methylation and associates with metastasis

FEZ1/LZTS1 is a tumor suppressor gene located in chromosomal band 8p22, and methylation has been identified as a mechanism for its loss of function in tumors. Chromosomal deletion at 8p22 is also frequent in breast cancer. We therefore examined whether LZTS1 plays a role in breast cancer. We analyze...

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Autores principales: Chen, Ling, Zhu, Zhengmao, Sun, Xiaodong, Dong, Xue-Yuan, Wei, Jia, Gu, Feng, Sun, Yu-Lan, Zhou, Jun, Dong, Jin-Tang, Fu, Li
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2927198/
https://ncbi.nlm.nih.gov/pubmed/18686028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-008-0147-6
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