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β-Peptides with improved affinity for hDM2 and hDMX

We previously described a series of 3(14)-helical β-peptides that bind the hDM2 protein and inhibit its interaction with a p53-derived peptide in vitro. Here we present a detailed characterization of the interaction of these peptides with hDM2 and report two new β-peptides in which non-natural side...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Harker, Elizabeth A., Daniels, Douglas S., Guarracino, Danielle A., Schepartz, Alanna
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2009
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2926950/
https://ncbi.nlm.nih.gov/pubmed/19211253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.01.039
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