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Molecular recognition of protein surfaces: High affinity ligands for the CBP KIX domain

Potent and specific inhibitors of protein•protein interactions have significant potential both as therapeutic compounds and biological tools, yet discovery of such molecules remains a significant challenge. Whereas small molecules typically bind proteins in small, well-defined, deep clefts, proteins...

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Detalhes bibliográficos
Main Authors: Rutledge, Stacey E., Volkman, Heather M., Schepartz, Alanna
Formato: Artigo
Idioma:Inglês
Publicado em: 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2926944/
https://ncbi.nlm.nih.gov/pubmed/14624582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja034508o
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