Are Cytochrome P450 CYP2C8 and CYP2C9 Polymorphisms Associated with Ibuprofen Response in Very Preterm Infants?

BACKGROUND: Patent ductus arteriosus (PDA) in extremely preterm infants remains a challenging condition with conflicting treatment strategies. Ibuprofen is currently used to treat PDA with ductal closure failure rate up to 40%. We test the hypothesis that cytochrome P450 CYP2C8/2C9 polymorphisms may...

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Autors principals: Durrmeyer, Xavier, Hovhannisyan, Shushanik, Médard, Yves, Jacqz-Aigrain, Evelyne, Decobert, Fabrice, Barre, Jérome, Alberti, Corinne, Aujard, Yannick, Danan, Claude, Baud, Olivier
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2010
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2925896/
https://ncbi.nlm.nih.gov/pubmed/20808793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012329
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