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The effect of the cytochrome P450 CYP2C8 polymorphism on the disposition of (R)-ibuprofen enantiomer in healthy subjects

AIMS: To study the effect of CYP2C8*3, the most common CYP2C8 variant allele on the dis-position of (R)-ibuprofen and the association of CYP2C8*3 with variant CYP2C9 alleles. METHODS: Three hundred and fifty-five randomly selected Spanish Caucasians were screened for the common CYP2C8 and CYP2C9 mut...

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Bibliografski detalji
Glavni autori: Martínez, Carmen, García-Martín, Elena, Blanco, Gerardo, Gamito, Francisco J G, Ladero, José M, Agúndez, José A G
Format: Artigo
Jezik:Inglês
Izdano: Blackwell Science Inc 2005
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884959/
https://ncbi.nlm.nih.gov/pubmed/15606441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2004.02183.x
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