Effect of grapefruit juice on the disposition of manidipine enantiomers in healthy subjects

AIM: To examine the effect of grapefruit juice, an inhibitor of CYP3A4 in the small intestine, on the disposition of manidipine enantiomers in healthy subjects. METHODS: A randomized cross-over study with at least a 2-week wash-out period was performed. Seven healthy male volunteers received an oral...

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Detaylı Bibliyografya
Asıl Yazarlar: Uno, Tsukasa, Ohkubo, Tadashi, Motomura, Shigeru, Sugawara, Kazunobu
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Blackwell Science Inc 2006
Konular:
Drug Disposition
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885066/
https://ncbi.nlm.nih.gov/pubmed/16669846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2006.02583.x
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