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RAPAMYCIN INHIBITS VEGF-INDUCED MICROVASCULAR HYPERPERMEABILITY IN VIVO

OBJECTIVE: To test the hypothesis that rapamycin inhibits induced microvascular hyperpermeability directly in vivo. METHODS: Male golden Syrian hamsters (80–120g) were treated with either rapamycin (at 0.1, 0.5, 2, and 10 mg/kg i.p.) or vehicle at 24 hours and at one hour prior to preparation of the...

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Main Authors: Kim, David D., Kleinman, David M., Kanetaka, Takehito, Gerritsen, Mary E., Nivaggioli, Thierry, Weber, David, Durán, Walter N.
格式: Artigo
語言:Inglês
出版: 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2925471/
https://ncbi.nlm.nih.gov/pubmed/20163539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1549-8719.2009.00012.x
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