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Synthesis and biological evaluation of new jasplakinolide (jaspamide) analogs

Synthesis and biological evaluation of jasplakinolide analogs are described. The synthesis of analogs utilized a diastereoselective syn-aldol reaction and an orthoester Claisen rearrangement as key steps. All synthetic analogs were evaluated for their ability to disrupt the actin cytoskeleton. Compo...

詳細記述

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書誌詳細
主要な著者: Ghosh, Arun K., Dawson, Zachary L., Moon, Deuk Kyu, Bai, Ruoli, Hamel, Ernest
フォーマット: Artigo
言語:Inglês
出版事項: 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2925441/
https://ncbi.nlm.nih.gov/pubmed/20678932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.07.023
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