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Engineered disulfide bonds restores chaperone like function of DJ-1 mutants linked to familial Parkinson’s disease
Loss-of-function mutations such as L166P, A104T and M26I in the DJ-1 gene (PARK7) have been linked to autosomal-recessive early onset Parkinson’s disease (PD). Cellular and structural studies of the familial mutants suggest that these mutations may destabilize the dimeric structure. In order to look...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2925438/ https://ncbi.nlm.nih.gov/pubmed/20527929 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi902164h |
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