Cathepsin B inhibition interferes with metastatic potential of human melanoma: an in vitro and in vivo study

BACKGROUND: Cathepsins represent a group of proteases involved in determining the metastatic potential of cancer cells. Among these are cysteinyl- (e.g. cathepsin B and cathepsin L) and aspartyl-proteases (e.g. cathepsin D), normally present inside the lysosomes as inactive proenzymes. Once released...

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Bibliographic Details
Main Authors: Matarrese, Paola, Ascione, Barbara, Ciarlo, Laura, Vona, Rosa, Leonetti, Carlo, Scarsella, Marco, Mileo, Anna M, Catricalà, Caterina, Paggi, Marco G, Malorni, Walter
Format: Artigo
Language:Inglês
Published: BioMed Central 2010
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2925371/
https://ncbi.nlm.nih.gov/pubmed/20684763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-207
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