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Structural and kinetic characterization of human deoxycytidine kinase variants able to phosphorylate 5-substituted deoxycytidine and thymidine analogs

The physiological role of human deoxycytidine kinase (dCK) is to phosphorylate deoxynucleosides required for DNA synthesis, with the exception of thymidine. Previous structural analysis of dCK implicated steric factors, specifically the thymine methyl group at the 5-position, that prevent thymidine...

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Autors principals: Hazra, Saugata, Ort, Stephan, Konrad, Manfred, Lavie, Arnon
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2925221/
https://ncbi.nlm.nih.gov/pubmed/20614893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100839e
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