Amyloid Beta Annular Protofibrils in Cell Processes and Synapses Accumulate with Aging and Alzheimer-Associated Genetic Modification

Amyloid β (Aβ) annular protofibrils (APFs) have been described where the structure is related to that of β barrel pore-forming bacterial toxins and exhibits cellular toxicity. To investigate the relationship of Aβ APFs to disease and their ultrastructural localization in brain tissue, we conducted a...

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Autors principals: Kokubo, Hideko, Kayed, Rakez, Glabe, Charles G., Staufenbiel, Matthias, Saido, Takaomi C., Iwata, Nobuhisa, Yamaguchi, Haruyasu
Format: Artigo
Idioma:Inglês
Publicat: SAGE-Hindawi Access to Research 2009
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2925098/
https://ncbi.nlm.nih.gov/pubmed/20798763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4061/2009/689285
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