Constitutively Nuclear FOXO3a Localization Predicts Poor Survival and Promotes Akt Phosphorylation in Breast Cancer

BACKGROUND: The PI3K-Akt signal pathway plays a key role in tumorigenesis and the development of drug-resistance. Cytotoxic chemotherapy resistance is linked to limited therapeutic options and poor prognosis. METHODOLOGY/PRINCIPAL FINDINGS: Examination of FOXO3a and phosphorylated-Akt (P-Akt) expres...

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Detalhes bibliográficos
Main Authors: Chen, Jie, Gomes, Ana R., Monteiro, Lara J., Wong, San Yu, Wu, Lai Han, Ng, Ting-Ting, Karadedou, Christina T., Millour, Julie, Ip, Ying-Chi, Cheung, Yuen Nei, Sunters, Andrew, Chan, Kelvin Y. K., Lam, Eric W.-F., Khoo, Ui-Soon
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2924889/
https://ncbi.nlm.nih.gov/pubmed/20808831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012293
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