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The inhaled glucocorticoid fluticasone propionate efficiently inactivates cytochrome P450 3A5, a predominant lung P450 enzyme

Inhaled glucocorticoid (GC) therapy is a vital part of the management of chronic asthma. GCs are metabolized by members of the cytochrome P450 3A family in both liver and lung, but the enzymes are differentially expressed. Selective inhibition of one or more P450 3A enzymes could substantially modif...

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Detalhes bibliográficos
Main Authors: Murai, Takahiro, Reilly, Christopher R., Ward, Robert M., Yost, Garold S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2924751/
https://ncbi.nlm.nih.gov/pubmed/20707410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx100124k
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