Enterohemorrhagic E. coli Requires N-WASP for Efficient Type III Translocation but Not for EspF(U)-Mediated Actin Pedestal Formation

Upon infection of mammalian cells, enterohemorrhagic E. coli (EHEC) O157:H7 utilizes a type III secretion system to translocate the effectors Tir and EspF(U) (aka TccP) that trigger the formation of F-actin-rich ‘pedestals’ beneath bound bacteria. EspF(U) is localized to the plasma membrane by Tir a...

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Hauptverfasser: Vingadassalom, Didier, Campellone, Kenneth G., Brady, Michael J., Skehan, Brian, Battle, Scott E., Robbins, Douglas, Kapoor, Archana, Hecht, Gail, Snapper, Scott B., Leong, John M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2010
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2924363/
https://ncbi.nlm.nih.gov/pubmed/20808845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1001056
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