Evidence that histidine protonation of receptor-bound anthrax protective antigen is a trigger for pore formation

The protective antigen (PA) component of the anthrax toxin forms pores within the low pH environment of host endosomes, through mechanisms that are poorly understood. It has been proposed that pore formation is dependent on histidine protonation. In previous work, we biosynthetically incorporated 2-...

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Bibliographic Details
Main Authors: Wimalasena, D. Shyamali, Janowiak, Blythe E., Lovell, Scott, Miyagi, Masaru, Sun, Jianjun, Zhou, Haiying, Hajduch, Jan, Pooput, Chaya, Kirk, Kenneth L., Battaile, Kevin P., Bann, James G.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2924283/
https://ncbi.nlm.nih.gov/pubmed/20672855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100647z
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