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GroEL as a molecular scaffold for structural analysis of the anthrax toxin pore

We analyzed the 440-kDa transmembrane pore formed by the protective antigen (PA) moiety of anthrax toxin in the presence of GroEL by negative-stain electron microscopy. GroEL binds both the heptameric PA prepore and the PA pore. The latter interaction retards aggregation of the pore, prolonging its...

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Detalhes bibliográficos
Main Authors: Katayama, Hiroo, Janowiak, Blythe E, Brzozowski, Marek, Juryck, Jordan, Falke, Scott, Gogol, Edward P, Collier, R John, Fisher, Mark T
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2504863/
https://ncbi.nlm.nih.gov/pubmed/18568038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1442
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