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GroEL as a molecular scaffold for structural analysis of the anthrax toxin pore
We analyzed the 440-kDa transmembrane pore formed by the protective antigen (PA) moiety of anthrax toxin in the presence of GroEL by negative-stain electron microscopy. GroEL binds both the heptameric PA prepore and the PA pore. The latter interaction retards aggregation of the pore, prolonging its...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2504863/ https://ncbi.nlm.nih.gov/pubmed/18568038 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1442 |
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