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Tyrosines in the Carboxyl Terminus Regulate Syk Kinase Activity and Function
The Syk tyrosine kinase family plays an essential role in immunoreceptor tyrosine-based activation motif (ITAM) signaling. The binding of Syk to tyrosine-phosphorylated ITAM subunits of immunoreceptors, such as FcϵRI on mast cells, results in a conformational change, with an increase of enzymatic ac...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2924109/ https://ncbi.nlm.nih.gov/pubmed/20554527 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.134262 |
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