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Novel Phorbol Ester-binding Motif Mediates Hormonal Activation of Na(+)/H(+) Exchanger
Protein kinase C (PKC) is considered crucial for hormonal Na(+)/H(+) exchanger (NHE1) activation because phorbol esters (PEs) strongly activate NHE1. However, here we report that rather than PKC, direct binding of PEs/diacylglycerol to the NHE1 lipid-interacting domain (LID) and the subsequent tight...
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| Hoofdauteurs: | , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Society for Biochemistry and Molecular Biology
2010
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2924106/ https://ncbi.nlm.nih.gov/pubmed/20551318 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.130120 |
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