Proteolysis-induced N-terminal Ectodomain Shedding of the Integral Membrane Glycoprotein CUB Domain-containing Protein 1 (CDCP1) Is Accompanied by Tyrosine Phosphorylation of Its C-terminal Domain and Recruitment of Src and PKCδ

CUB-domain-containing protein 1 (CDCP1) is an integral membrane glycoprotein with potential as a marker and therapeutic target for a number of cancers. Here we examine mechanisms regulating cellular processing of CDCP1. By analyzing cell lines exclusively passaged non-enzymatically and through use o...

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Main Authors: He, Yaowu, Wortmann, Andreas, Burke, Les J., Reid, Janet C., Adams, Mark N., Abdul-Jabbar, Ibtissam, Quigley, James P., Leduc, Richard, Kirchhofer, Daniel, Hooper, John D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2924022/
https://ncbi.nlm.nih.gov/pubmed/20551327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.096453
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