Aryl Phosphoramidates of 5-Phospho Erythronohydroxamic Acid, A New Class of Potent Trypanocidal Compounds

[Image: see text] RNAi and enzymatic studies have shown the importance of 6-phosphogluconate dehydrogenase (6-PGDH) in Trypanosoma brucei for the parasite survival and make it an attractive drug target for the development of new treatments against human African trypanosomiasis. 2,3-O-Isopropylidene-...

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Autori principali: Ruda, Gian Filippo, Wong, Pui Ee, Alibu, Vincent P., Norval, Suzanne, Read, Kevin D., Barrett, Michael P., Gilbert, Ian H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2010
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2923871/
https://ncbi.nlm.nih.gov/pubmed/20666371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm1004754
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