PGE(2) contributes to TGF-β induced T regulatory cell function in human non-small cell lung cancer

CD4(+)CD25(bright) regulatory T cells (T(reg)) play an important role in cancer-mediated immunosuppression. We and others have previously shown that prostaglandin E2 (PGE(2)) and transforming growth factor beta (TGF-β) induce CD4(+)CD25(bright)FOXP3(+)T(reg). Based on these studies, we investigated...

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Detalhes bibliográficos
Main Authors: Baratelli, Felicita, Lee, Jay M, Hazra, Saswati, Lin, Ying, Walser, Tonya C, Schaue, Dorthe, Pak, Peter S, Elashoff, David, Reckamp, Karen, Zhang, Ling, Fishbein, Michael C, Sharma, Sherven, Dubinett, Steven M
Formato: Artigo
Idioma:Inglês
Publicado em: e-Century Publishing Corporation 2010
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2923860/
https://ncbi.nlm.nih.gov/pubmed/20733946
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