Pre-clinical characterization of GMP grade CCL21-gene modified dendritic cells for application in a phase I trial in Non-Small Cell Lung Cancer

BACKGROUND: Our previous studies have demonstrated that transduction of human dendritic cells (DC) with adenovirus encoding secondary lymphoid chemokine, CCL21, led to secretion of biologically active CCL21 without altering DC phenotype or viability. In addition, intratumoral injections of CCL21-tra...

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Autores principales: Baratelli, Felicita, Takedatsu, Hiroko, Hazra, Saswati, Peebles, Katherine, Luo, Jie, Kurimoto, Pam S, Zeng, Gang, Batra, Raj K, Sharma, Sherven, Dubinett, Steven M, Lee, Jay M
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2008
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2507704/
https://ncbi.nlm.nih.gov/pubmed/18644162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-6-38
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